As farmers focus on yield-robbing insects, new tools are being added to the toolbox. For the 2026 crop year, the EPA has registered NewLeaf Symbiotic’s TS201 bioinsecticide for use on corn, soybeans, cotton and rice. This product is applied at the time of planting in the planter box.
“TS201 uses a mode of action called induced systemic resistance (ISR) to deliver added defenses in-season,” Aaron Kelley, chief commercial officer for NewLeaf Symbiotics said in a press release. “ISR primes the plant’s natural defenses against a number of pests, making it quicker to react to known threats in season. You’re not waiting on your scout to start to fight against the threat, your plant is the first line of defense.”
NewLeaf lists TS201 for use in the following crops with protection against the following pests:
• Corn: Corn Rootworm, Root Knot Nematode, Wireworm, Fall Armyworm
• Soybeans: Stink Bugs, Root Knot Nematode, Soybean Looper
• Cotton: Root Knot Nematode, Thrips
• Rice: Rice Water Weevil
NewLeaf’s biological product portfolio builds on its development using Pink-Pigmented Facultative Methylotrophs (PPFMs). First launched in 2024, TS201 was registered as a corn bioinsecticide to repel corn rootworm larvae.
In company-reported results, NewLeaf says using TS201 with its Terrasym 450 biostimulant produced a corn yield gain of 8.7 bu./acre in 10+ acre field trials conducted across 91 locations from 2023–2025.


